2. Membrane Transporter/Ion Channel Autophagy
  3. Potassium Channel Autophagy
  4. Amiodarone-d4 hydrochloride

Amiodarone-d4 (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

For research use only. We do not sell to patients.

Amiodarone-d<sub>4</sub> hydrochloride Chemical Structure

Amiodarone-d4 hydrochloride Chemical Structure

CAS No. : 1216715-80-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Amiodarone-d4 hydrochloride:

Amiodarone-d4 hydrochloride Related Antibodies

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Description

Amiodarone-d4 (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amiodarone-d4 hydrochloride Related Antibodies
Molecular Weight

685.80

Formula

C25H26D4ClI2NO3
CAS No.
Unlabeled CAS

19774-82-4
Appearance

Solid

Color

White to off-white

SMILES

CCCCC1=C(C(C2=CC(I)=C(OC([2H])([2H])C([2H])([2H])N(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 10 mg/mL (14.58 mM)

DMF : ≥ 10 mg/mL (14.58 mM)

DMSO : ≥ 10 mg/mL (14.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 10 mg/mL (14.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 5 mg/mL (7.29 mM)

Ethanol : ≥ 5 mg/mL (7.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4582 mL 7.2908 mL 14.5815 mL
5 mM 0.2916 mL 1.4582 mL 2.9163 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol / DMF / DMF / DMSO / DMSO 1 mM 1.4582 mL 7.2908 mL 14.5815 mL 36.4538 mL
5 mM 0.2916 mL 1.4582 mL 2.9163 mL 7.2908 mL
DMF / DMF / DMSO / DMSO 10 mM 0.1458 mL 0.7291 mL 1.4582 mL 3.6454 mL
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Amiodarone-d4 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amiodarone-d41216715-80-8Potassium ChannelAutophagyKcsAInhibitorinhibitorinhibit

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