2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. AMP-PNP tetralithium

AMP-PNP tetralithium  (Synonyms: Adenylyl-imidodiphosphate tetralithium)

Cat. No.: HY-128933 Purity: ≥97.0%
COA Handling Instructions

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AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels.

For research use only. We do not sell to patients.

AMP-PNP tetralithium Chemical Structure

AMP-PNP tetralithium Chemical Structure

CAS No. : 72957-42-7

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Based on 1 publication(s) in Google Scholar

Other Forms of AMP-PNP tetralithium:

AMP-PNP tetralithium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AMP-PNP tetralithium

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  • Purity & Documentation

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  • Customer Review

Description

AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels[1][2].

In Vitro

AMP-PNP (5 to 500 μM; Li salt) reduced the open-probability po of KATP channels and decreases the single-channel currents at high nucleotide concentrations by approximately 10%[2].
AMP-PNP inhibits KATP channels of ventricular myocytes and of pancreatic β-cells both in the absence and presence of Mg2+ ions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMP-PNP tetralithium Related Antibodies
Molecular Weight

529.93

Formula

C10H13Li4N6O12P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](N2C3=C(N=C2)C(N)=NC=N3)O[C@@H]([C@H]1O)COP(OP(NP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 26.5 mg/mL (50.01 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8870 mL 9.4352 mL 18.8704 mL
5 mM 0.3774 mL 1.8870 mL 3.7741 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8870 mL 9.4352 mL 18.8704 mL 47.1760 mL
5 mM 0.3774 mL 1.8870 mL 3.7741 mL 9.4352 mL
10 mM 0.1887 mL 0.9435 mL 1.8870 mL 4.7176 mL
15 mM 0.1258 mL 0.6290 mL 1.2580 mL 3.1451 mL
20 mM 0.0944 mL 0.4718 mL 0.9435 mL 2.3588 mL
25 mM 0.0755 mL 0.3774 mL 0.7548 mL 1.8870 mL
30 mM 0.0629 mL 0.3145 mL 0.6290 mL 1.5725 mL
40 mM 0.0472 mL 0.2359 mL 0.4718 mL 1.1794 mL
50 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9435 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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AMP-PNP tetralithium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMP-PNP tetralithium72957-42-7Adenylyl-imidodiphosphate tetralithiumPotassium ChannelKcsAInhibitorinhibitorinhibit

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