2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. AMPK activator 8

AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes.

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AMPK activator 8 Chemical Structure

AMPK activator 8 Chemical Structure

CAS No. : 1852451-96-7

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AMPK activator 8 Related Antibodies

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Description

AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK) activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of type 2 diabetes[1].

IC50 & Target

AMPK α1β1γ1

11 nM (EC50)

AMPK α2β1γ1

27 nM (EC50)

AMPK α1β2γ1

4 nM (EC50)

AMPK α2β2γ1

2 nM (EC50)

In Vitro

AMPK activator 8 (compound 2) acts on rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ and rAMPK α2β2γ3 with the EC50 value of 11 nM, 27 nM, 4 nM, 2 nM and 4 nM, respectively[1].
AMPK activator 8 (compound 2) affects cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMPK activator 8 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2, C2C12 myoblasts
Concentration: 0.01-1000 μM
Incubation Time: 1 hour
Result: Resulted in HepG2 and C2C12 myoblasts with the EC50 value of 255 nM and 230 nM, respectively.
Molecular Weight

480.90

Formula

C25H21ClN2O6
CAS No.
SMILES

ClC1=C(C2=CC=C(C3=C(C=CC=C3O)O)C=C2)C=C4NC(O[C@H]5[C@]6([H])[C@]([C@@H](CO6)O)([H])OC5)=NC4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AMPK activator 8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMPK activator 81852451-96-7AMPK activator8AMPK activator-8AMPKAMP-activated protein kinaseAMPK?activatortype 2 diabetesInhibitorinhibitorinhibit

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