2. GPCR/G Protein
  3. Bradykinin Receptor
  4. Anatibant hydrochloride

Anatibant hydrochloride  (Synonyms: LF 16-0687 hydrochloride; XY-2405 hydrochloride)

Cat. No.: HY-121156A
Handling Instructions

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Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with Ki values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases.

For research use only. We do not sell to patients.

Anatibant hydrochloride Chemical Structure

Anatibant hydrochloride Chemical Structure

CAS No. : 209788-45-4

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1 mg USD 1230 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Anatibant hydrochloride:

Anatibant hydrochloride Related Antibodies

Top Publications Citing Use of Products

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Bradykinin B1 Receptor (B1R) Bradykinin B2 Receptor (B2R)

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Description

Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with Ki values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases[1][2].

IC50 & Target[1][2]

Bradykinin B2 Receptor (B2R)

0.67 nM (Ki, human recombinant B2 receptor )

Bradykinin B2 Receptor (B2R)

1.74 nM (Ki, Rat recombinant B2 receptor )

Bradykinin B2 Receptor (B2R)

1.37 nM (Ki, Guinea-pig recombinant B2 receptor )

Molecular Weight

784.58

Formula

C34H38Cl4N6O5S
CAS No.
Appearance

Solid

SMILES

O=C(NCCCNC(C1=CC=C(C=C1)C(N)=N)=O)[C@H]2N(CCC2)S(=O)(C3=CC=C(C(COC4=C5N=C(C=C(C5=CC=C4)C)C)=C3Cl)Cl)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (70.10 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2746 mL 6.3728 mL 12.7457 mL
5 mM 0.2549 mL 1.2746 mL 2.5491 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2746 mL 6.3728 mL 12.7457 mL 31.8642 mL
5 mM 0.2549 mL 1.2746 mL 2.5491 mL 6.3728 mL
10 mM 0.1275 mL 0.6373 mL 1.2746 mL 3.1864 mL
15 mM 0.0850 mL 0.4249 mL 0.8497 mL 2.1243 mL
20 mM 0.0637 mL 0.3186 mL 0.6373 mL 1.5932 mL
25 mM 0.0510 mL 0.2549 mL 0.5098 mL 1.2746 mL
30 mM 0.0425 mL 0.2124 mL 0.4249 mL 1.0621 mL
40 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7966 mL
50 mM 0.0255 mL 0.1275 mL 0.2549 mL 0.6373 mL
60 mM 0.0212 mL 0.1062 mL 0.2124 mL 0.5311 mL
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Anatibant hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anatibant209788-45-4LF 16-0687XY-2405XY2405XY 2405Bradykinin ReceptorBradykinin B2 Receptor Antagonistblood-brain barrierbrain damage diseasesInhibitorinhibitorinhibit

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