2. PROTAC
  3. PROTAC Linkers
  4. ANB-NOS

ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. ANB-NOS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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ANB-NOS Chemical Structure

ANB-NOS Chemical Structure

CAS No. : 60117-35-3

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Based on 1 publication(s) in Google Scholar

ANB-NOS Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. ANB-NOS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ANB-NOS Related Antibodies
Molecular Weight

305.20

Formula

C11H7N5O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(CCC1=O)=O)C2=CC(N=[N+]=[N-])=CC=C2[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (409.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2765 mL 16.3827 mL 32.7654 mL
5 mM 0.6553 mL 3.2765 mL 6.5531 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2765 mL 16.3827 mL 32.7654 mL 81.9135 mL
5 mM 0.6553 mL 3.2765 mL 6.5531 mL 16.3827 mL
10 mM 0.3277 mL 1.6383 mL 3.2765 mL 8.1913 mL
15 mM 0.2184 mL 1.0922 mL 2.1844 mL 5.4609 mL
20 mM 0.1638 mL 0.8191 mL 1.6383 mL 4.0957 mL
25 mM 0.1311 mL 0.6553 mL 1.3106 mL 3.2765 mL
30 mM 0.1092 mL 0.5461 mL 1.0922 mL 2.7304 mL
40 mM 0.0819 mL 0.4096 mL 0.8191 mL 2.0478 mL
50 mM 0.0655 mL 0.3277 mL 0.6553 mL 1.6383 mL
60 mM 0.0546 mL 0.2730 mL 0.5461 mL 1.3652 mL
80 mM 0.0410 mL 0.2048 mL 0.4096 mL 1.0239 mL
100 mM 0.0328 mL 0.1638 mL 0.3277 mL 0.8191 mL
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ANB-NOS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANB-NOS60117-35-3PROTAC LinkersInhibitorinhibitorinhibit

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