2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Androsta-1,4,6-triene-3,17-dione

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory.

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Androsta-1,4,6-triene-3,17-dione Chemical Structure

Androsta-1,4,6-triene-3,17-dione Chemical Structure

CAS No. : 633-35-2

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Androsta-1,4,6-triene-3,17-dione Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Androsta-1,4,6-triene-3,17-dione is a lipophilic and specific aromatase inhibitor with a Ki of 0.18 μM. Androsta-1,4,6-triene-3,17-dione inhibits estrogen biosynthesis and shows antifertility effects. Androsta-1,4,6-triene-3,17-dione induces impairment of spatial memory[1][2].

IC50 & Target

Aromatase

 

In Vivo

Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2].
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (220-250 g)[2]
Dosage: 25 mg/kg, 100 mg/kg
Administration: Subcutaneous injection
Result: Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus.
Molecular Weight

282.38

Formula

C19H22O2
CAS No.
SMILES

C[C@]1([C@](CC2)([H])[C@]3([H])C=CC4=CC(C=C[C@]4(C)[C@@]3([H])CC1)=O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Androsta-1,4,6-triene-3,17-dione Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Androsta-1,4,6-triene-3,17-dione633-35-2Cytochrome P450CYPshippocampusHPestrogensynthetaseantifertilityspatialmemoryimpairmentInhibitorinhibitorinhibit

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