2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel
  4. Annonacin

Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Annona muricata to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps.

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Annonacin Chemical Structure

Annonacin Chemical Structure

CAS No. : 111035-65-5

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Annonacin Related Antibodies

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Description

Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Annona muricata to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps[1].

Molecular Weight

596.88

Formula

C35H64O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1O[C@@H](C)C=C1C[C@H](O)CCCCC[C@@H](O)CCCC[C@@H](O)[C@@H]2O[C@@H]([C@H](O)CCCCCCCCCCCC)CC2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (33.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6754 mL 8.3769 mL 16.7538 mL
5 mM 0.3351 mL 1.6754 mL 3.3508 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (241 KB) HNMR (189 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6754 mL 8.3769 mL 16.7538 mL 41.8845 mL
5 mM 0.3351 mL 1.6754 mL 3.3508 mL 8.3769 mL
10 mM 0.1675 mL 0.8377 mL 1.6754 mL 4.1884 mL
15 mM 0.1117 mL 0.5585 mL 1.1169 mL 2.7923 mL
20 mM 0.0838 mL 0.4188 mL 0.8377 mL 2.0942 mL
25 mM 0.0670 mL 0.3351 mL 0.6702 mL 1.6754 mL
30 mM 0.0558 mL 0.2792 mL 0.5585 mL 1.3961 mL
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Annonacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Annonacin111035-65-5Potassium ChannelSodium ChannelNa+/K+ ATPaseCalcium ChannelKcsANa channelsNa+ channelsSodium potassium pumpCa2+ channelsCa channelsAcetogenincytotoxicitymitochondrialsodiumpotassiumsarcoplasmicreticulumATPaseInhibitorinhibitorinhibit

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