2. Apoptosis
  3. Apoptosis
  4. Anti-CSCs agent-1

Anti-CSCs agent-1 is a potent anti-CSCs agent. Anti-CSCs agent-1 inhibits cell growth and cell migration. Anti-CSCs agent-1 induces Apoptosis. Anti-CSCs agent-1 inhibits the viability of CSCs. Anti-CSCs agent-1 enhances the production of ROS in CSCs. Anti-CSCs agent-1 shows antitumor activity.

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Anti-CSCs agent-1 Chemical Structure

Anti-CSCs agent-1 Chemical Structure

CAS No. : 2251753-58-7

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Anti-CSCs agent-1 Related Antibodies

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Description

Anti-CSCs agent-1 is a potent anti-CSCs agent. Anti-CSCs agent-1 inhibits cell growth and cell migration. Anti-CSCs agent-1 induces Apoptosis. Anti-CSCs agent-1 inhibits the viability of CSCs. Anti-CSCs agent-1 enhances the production of ROS in CSCs. Anti-CSCs agent-1 shows antitumor activity[1].

In Vitro

Anti-CSCs agent-1 (compound 48) (0, 0.25, 0.5 µM) inhibits the colony formation and cell migration in A375 and B16F10 cells in a dose-dependent manner[1].
Anti-CSCs agent-1 (0, 1, 2, 3, 4 µM; 48 h) induces apoptosis with increases in the expression of cleaved PARP, cleaved caspase-3, P-53 and Bax in a dose-dependent manner[1].
Anti-CSCs agent-1 (0, 0.25, 0.5, 1.0, 2.0 µM; 24 h) reverses epithelial-mesenchymal transition (EMT) by significantly upregulating the expression of E-cadherin in a dose-dependent manner[1].
Anti-CSCs agent-1 (0-10 µM; 15 days) inhibits the viability of cancer stem cells (CSCs) with IC50s of 3.04, 1.24 µM for spheriod A357, B16F10 cells, respectively[1].
Anti-CSCs agent-1 (0-2 µM; 24 h) markedly enhances the production of ROS in CSCs in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-CSCs agent-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, 4T1, A375, B16F10, PANC-1, A549, LLC cells
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 3.152, 0.7401, 0.8929, 0.6744, 1.107, 11.56, 0.9066 µM for MDA-MB-231, 4T1, A375, B16F10, PANC-1, A549, LLC cells, respectively.

Apoptosis Analysis[1]

Cell Line: A375, B16F10 cells
Concentration: 0, 1, 2, 3 µM
Incubation Time: 48 h
Result: Induced cell apoptosis in a dose-dependen manner.

Western Blot Analysis[1]

Cell Line: A375, B16F10 cells
Concentration: 0, 1, 2, 3, 4 µM
Incubation Time: 48 h
Result: Increased the expression of cleaved PARP, cleaved casepase-3, P-53 and Bax in a dose-dependent manner.
In Vivo

Anti-CSCs agent-1 (5 mg/kg; i.p.; daily for 15 days) shows antitumor activity in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (A375 cells)[1]
Dosage: 5 mg/kg
Administration: I.p.; daily for 15 days
Result: Significantly inhibited tumor growth.
Molecular Weight

713.96

Formula

C44H60FN3O4
CAS No.
SMILES

O=C(C1(CC1)C(NC2=CC=C(C=C2)F)=O)NCCNC([C@]34[C@](CC(C)(CC4)C)([H])C5=CC[C@@]([C@@]6([C@@](C(C)(C(C(C6)=C)=O)C)([H])CC7)C)([H])[C@]7(C)[C@@]5(CC3)C)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Anti-CSCs agent-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CSCs agent-12251753-58-7ApoptosismigrationROSantitumorEMTA375B16F10 cellsantiproliferativeapoptosisInhibitorinhibitorinhibit

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