2. NF-κB Stem Cell/Wnt JAK/STAT Signaling Immunology/Inflammation Apoptosis
  3. NF-κB STAT Interleukin Related TNF Receptor
  4. Anti-inflammatory agent 91

Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that can reduce inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. Anti-inflammatory agent 91 can be used in research to improve skin inflammation associated with psoriasis.

For research use only. We do not sell to patients.

Anti-inflammatory agent 91 Chemical Structure

Anti-inflammatory agent 91 Chemical Structure

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Anti-inflammatory agent 91 Related Antibodies

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Description

Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that can reduce inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. Anti-inflammatory agent 91 can be used in research to improve skin inflammation associated with psoriasis[1].

In Vitro

Anti-inflammatory agent 91 (Compound 4o) (10-80 μM; 24 h) has no significant effect on HaCaT cell viability[1].
Anti-inflammatory agent 91 (10-40 μM; 2 h) significantly reduces NO (IC50= 19.5 μM), TNF-α, IL-6 (RAW264.7) and IL-17A (HaCaT) levels in LPS (1 μg/mL; 24 h)-induced RAW264.7 and HaCaT cells, demonstrating anti-inflammatory activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 91 Related Antibodies
In Vivo

Anti-inflammatory agent 91 (Compound 4o) (25-100 mg/kg; apply topically to skin once daily for 5 days) can ameliorate psoriasis in imiquimod (HY-B0180)-induced psoriatic mice by inhibiting inflammatory cytokines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Imiquimod-induced Psoriasis mice model[1].
Dosage: 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: Apply topically to skin once daily for 5 days. 12 hours after applying 5% imiquimod cream.
Result: Significantly inhibited the expression of inflammatory factors IL-6, IL-17A, IL-22, IL-23, and TNF-α in the serum of IMQ-induced psoriasis-like mice.
Significantly reduced the erythema and scales of the dorsal lesions of the mice compared to the imiquimod (IMQ) group.
Significantly reduced histopathological damage.
Effectively inhibited the expression of p65, STAT3, and p-STAT3, and slightly reduced the expression of p-p65.
Molecular Weight

507.89

Formula

C23H16ClF2NO6S
SMILES

O=S(C1=CC(F)=C(Cl)C=C1F)(NCCOC2=CC3=C(C(O)=C2)C(C=C(C4=CC=CC=C4)O3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 91 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 91NF-κBSTATInterleukin RelatedTNF ReceptorNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRRAW264.7 cellPsoriasisBalb/c miceHaCaTInhibitorinhibitorinhibit

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Anti-inflammatory agent 91
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