Anti-inflammatory agent 91 

Anti-inflammatory agent 91 (Compound 4o) is an anti-inflammatory agent that can reduce inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. Anti-inflammatory agent 91 can be used in research to improve skin inflammation associated with psoriasis^[1].

Anti-inflammatory agent 91 (Compound 4o) (10-80 μM; 24 h) has no significant effect on HaCaT cell viability^[1].
Anti-inflammatory agent 91 (10-40 μM; 2 h) significantly reduces NO (IC₅₀= 19.5 μM), TNF-α, IL-6 (RAW264.7) and IL-17A (HaCaT) levels in LPS (1 μg/mL; 24 h)-induced RAW264.7 and HaCaT cells, demonstrating anti-inflammatory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 91 (Compound 4o) (25-100 mg/kg; apply topically to skin once daily for 5 days) can ameliorate psoriasis in imiquimod (HY-B0180)-induced psoriatic mice by inhibiting inflammatory cytokines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

507.89

C₂₃H₁₆ClF₂NO₆S

O=S(C1=CC(F)=C(Cl)C=C1F)(NCCOC2=CC3=C(C(O)=C2)C(C=C(C4=CC=CC=C4)O3)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhao X, et al. Discovery of novel chrysin derivatives as potential Anti-Psoriasis agents[J]. Bioorganic Chemistry, 2024, 150: 107599.  [Content Brief]