2. NF-κB
  3. NF-κB
  4. Anti-inflammatory agent 93

Anti-inflammatory agent 93 (Compound 3q) is a potent cholinergic anti-inflammatory pathway (CAP) activators. Anti-inflammatory agent 93 inhibits Monosodium urate (MSU) (HY-B2130A)-induced IL-1β production in THP-1 cells, indicating its potential against gout arthritis. Anti-inflammatory agent 93 inhibits MSU induced phosphorylation of NF-κB p65, without any inhibitory effect against NLRP3, pro-caspase 1, or the self-cleavage and activation of caspase-1 of the second signaling. Therefore, Anti-inflammatory agent 93 inhibits the initial phase of NLRP3 through CAP activation.

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Anti-inflammatory agent 93 Chemical Structure

Anti-inflammatory agent 93 Chemical Structure

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Anti-inflammatory agent 93 Related Antibodies

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Description

Anti-inflammatory agent 93 (Compound 3q) is a potent cholinergic anti-inflammatory pathway (CAP) activators. Anti-inflammatory agent 93 inhibits Monosodium urate (MSU) (HY-B2130A)-induced IL-1β production in THP-1 cells, indicating its potential against gout arthritis. Anti-inflammatory agent 93 inhibits MSU induced phosphorylation of NF-κB p65, without any inhibitory effect against NLRP3, pro-caspase 1, or the self-cleavage and activation of caspase-1 of the second signaling. Therefore, Anti-inflammatory agent 93 inhibits the initial phase of NLRP3 through CAP activation[1].

Molecular Weight

388.55

Formula

C26H32N2O
SMILES

CC1=CC(C)=CC(C)=C1OC2=NC(C[C@H]3[C@](C=C)([H])[C@]4(N(C)C)CC(C)=C3)=C4C=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Anti-inflammatory agent 93 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 93NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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