2. Apoptosis
  3. Apoptosis
  4. Anti-melanoma agent 1

Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent and induces cell apoptosis.

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Anti-melanoma agent 1 Chemical Structure

Anti-melanoma agent 1 Chemical Structure

CAS No. : 2418579-17-4

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Based on 1 publication(s) in Google Scholar

Anti-melanoma agent 1 Related Antibodies

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Description

Anti-melanoma agent 1 (Compound 5m) is an anti-melanoma agent and induces cell apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
1.98 μM
Compound: 5m
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
SK-MEL-28 IC50
3.3 μM
Compound: 5m
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
SK-MEL-5 IC50
3.7 μM
Compound: 5m
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 32216987]
In Vitro

Anti-melanoma agent 1 (Compound 5m) (0-100 μM, 48 h) shows antiproliferative activity against melanoma cells[1].
Anti-melanoma agent 1 (0-10 μM) inhibits colony formation in SK-MEL-28[1].
Anti-melanoma agent 1 (1 and 2 μM) induces cell apoptosis (24 h), arrests cell cycle at G2/M phase (12 h), inhibits cell migration (48 h) and disrupts the cellular microtubule network[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-melanoma agent 1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SK-MEL-5, SK-MEL-28 and A375
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50 values of 3.70 ± 0.17, 3.30 ± 0.06 and 1.98 ± 0.10 μM against SK-MEL-5, SK-MEL-28 and A375 cells, respectively.

Apoptosis Analysis[1]

Cell Line: SK-MEL-28
Concentration: 1 μM and 2 μM
Incubation Time: 24 h
Result: Induced cell apoptosis.

Cell Cycle Analysis[1]

Cell Line: SK-MEL-28
Concentration: 1 μM and 2 μM
Incubation Time: 12 h
Result: Arrested cell cycle at G2/M phase.

Cell Migration Assay [1]

Cell Line: SK-MEL-28
Concentration: 1 μM and 2 μM
Incubation Time: 48 h
Result: Inhibited cell migration.
Molecular Weight

424.53

Formula

C28H28N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CNCC1=CC=C(C2=CC=CC=C2)C=C1)COC3=CC=CC(NC4=CC=CC=C4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (235.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3555 mL 11.7777 mL 23.5555 mL
5 mM 0.4711 mL 2.3555 mL 4.7111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3555 mL 11.7777 mL 23.5555 mL 58.8887 mL
5 mM 0.4711 mL 2.3555 mL 4.7111 mL 11.7777 mL
10 mM 0.2356 mL 1.1778 mL 2.3555 mL 5.8889 mL
15 mM 0.1570 mL 0.7852 mL 1.5704 mL 3.9259 mL
20 mM 0.1178 mL 0.5889 mL 1.1778 mL 2.9444 mL
25 mM 0.0942 mL 0.4711 mL 0.9422 mL 2.3555 mL
30 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9630 mL
40 mM 0.0589 mL 0.2944 mL 0.5889 mL 1.4722 mL
50 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1778 mL
60 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL
80 mM 0.0294 mL 0.1472 mL 0.2944 mL 0.7361 mL
100 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5889 mL
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Anti-melanoma agent 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-melanoma agent 12418579-17-4ApoptosisSK-MEL-28anti-melanomapropranololInhibitorinhibitorinhibit

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