Anti-MRSA agent 7 

Anti-MRSA agent 7 (Compound 12) is a potent antibacterial agent. Anti-MRSA agent 7 inhibits S. aureus DNA gyrase, E. coli DNA gyrase, S. aureus topo IV and E. coli topo IV with IC₅₀s of 0.185, 0.365, 0.341 and 0.059 μM, respectively^[1].

Anti-MRSA agent 7 (Compound 12) shows a dose-dependent killing efficacy achieving bactericidal effect against planktonic methicillin-resistant S. aureus (ATCC 43300) at 8 × MIC after 8 h of treatment, after which re-growth occurs^[1].
Antimicrobial activity of Anti-MRSA agent 7 (Compound 12) against a panel of Gram-positive and Gram-negative bacterial pathogens^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-MRSA agent 7 (Compound 12; 20 and 40 mg/kg; i.p.; QID for 1 day) demonstrates high in vivo efficacy in MRSA neutropenic mouse thigh infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

508.31

C₂₂H₂₀BrF₂N₃O₄

COC1=NC2=C(N=CC=C2OC[C@H]3CC[C@@H](CO3)NC(C4=CC(F)=C(C(F)=C4)Br)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kokot M, et al. Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy. Eur J Med Chem. 2023 Mar 15;250:115160.  [Content Brief]