Factor X Antibody (YA1349)

Factor X Antibody (YA1349) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1349), targeting Factor X, with a predicted molecular weight of 55 kDa (observed band size: 74 kDa). Factor X Antibody (YA1349) can be used for WB, IHC-P experiment in human background.

The related gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. The factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of The related gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to related generate mature polypeptides.

2159

Predicted band size: 55 kDa; Observed band size: 74 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Cardiovascular

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

P00742

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Factor X