LRP2/Megalin Antibody(YA3473)

LRP2/Megalin Antibody(YA3473) is a non-conjugated IgG antibody, targeting LRP2, with a predicted molecular weight of 522 kDa (observed band size: 600 kDa). LRP2 Antibody (YA3473) can be used for WB, IHC-P, IF-Tissue experiment in human, mouse, rat background.

The protein encoded by The related gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. The glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. The protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of The membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in The related gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

4036

Predicted band size: 522 kDa; Observed band size: 600 kDa

affinity purified.

Apical cell membrane, Endosome lumen, Membrane, coated pit, Cell projection, dendrite, axon.

Non-conjugated

Unmodified

Cardiovascular

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human, Mouse, Rat

P98164

WB: 1:2,000;IHC-P: 1:1,000;IF-Tissue: 1:200

WB, IHC-P, ICC/IF

Human kidney tissue lysate, mouse kidney tissue lysate, rat kidney tissue lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue.

Liquid

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Synthetic peptide within human Lrp2 aa 2,500-3,200 / 4,655.