Mast Cell Tryptase Antibody (YA1533)

Mast Cell Tryptase Antibody (YA1533) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1533), targeting Mast Cell Tryptase, with a predicted molecular weight of 31 kDa. Mast Cell Tryptase Antibody (YA1533) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase related genes are clustered on chromosome 16p13.3. These related genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These related genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. The feature is characteristic of tryptases but is unusual in other related genes. The alleles of The related gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate related genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathorelated genesis of asthma and other allergic and inflammatory disorders.

7177

Predicted band size: 31 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

Q15661

WB: 1/500-1/1000;IHC: 1/50-1/100;IP: 1/50

WB, IHC-P, IP

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Mast Cell Tryptase