MPZ Antibody

MPZ Antibody is a rabbit-derived non-conjugated IgG antibody, targeting MPZ, with a predicted molecular weight of 28 kDa (observed band size: 28 kDa). MPZ Antibody can be used for WB experiments in rat backgrounds.

The related gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in The related gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

4359

Predicted band size: 28 kDa;Observed band size: 28 kDa

Affinity Purified

Cell membrane

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Polyclonal

Rabbit

Rat

P25189

WB: 1/500-1/1000

WB

Liquid

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

Recombinant protein of human Myelin Protein Zero.