Neutrophil Elastase Antibody

Neutrophil Elastase Antibody is an unconjugated, approximately 26 kDa, rabbit-derived, anti-Neutrophil Elastase monoclonal antibody. Neutrophil Elastase Antibody can be used for: WB,IHC-P,ICC/IF,FC expriments in human background without labeling.

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase related genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to related generate the active protease. Following activation, The protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in derelated generative and inflammatory diseases through proteolysis of collagen-IV and elastin. The protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in The related gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). The related gene is present in a related gene cluster on chromosome 19.

1991

Predicted band size: 26kDa

affinity purified

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human

P08246

WB: 1/500-1/1000; IHC: 1/50-1/100; IF: 1/50-1/200; FC: 1/50-1/100;

WB, IHC-P, ICC/IF, FC

Liquid

Supplied in Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Neutrophil Elastase.