Phospho-MLKL (Ser358) Antibody (YA1623)

Phospho-MLKL (Ser358) Antibody (YA1623) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-MLKL (Ser358), with a predicted molecular weight of 54 kDa. Phospho-MLKL (Ser358) Antibody (YA1623) can be used for WB, IHC-P experiment in human background.

The related gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. The protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of The related gene inhibited TNF-induced necrosis. High levels of The protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for The related gene.

197259

Predicted band size: 54 kDa

Affinity Chromatography

Non-conjugated

Phosphorylated

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q8NB16

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human Phospho-MLKL (S358)