TOP2A Antibody

TOP2A Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 174 kDa, targeting to TOP2A. It can be used for WB, IHC-P, IP assays with tag free, in the background of Human, Mouse, Rat.

The related gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. The nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of The enzyme exist as likely products of a related gene duplication event. The related gene encoding The form, alpha, is localized to chromosome 17 and the beta related gene is localized to chromosome 3. The related gene encoding The enzyme functions as the target for several anticancer agents and a variety of mutations in The related gene have been associated with the development of drug resistance. Reduced activity of The enzyme may also play a role in ataxia-telangiectasia.

Virus

7153

Predicted band size: 174 kDa

Protein A affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P11388

WB: 1:500-1:1000 ;IHC: 1:50-1:100 ;IP: 1:20

WB, IHC-P, IP

Liquid

Supplied in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous