2. Apoptosis
  3. Ferroptosis
  4. Anticancer agent 147

Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo.

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Anticancer agent 147 Chemical Structure

Anticancer agent 147 Chemical Structure

CAS No. : 2241283-11-2

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Description

Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
3.5 μM
Compound: 6j
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30025344]
CNE-2 IC50
4.3 μM
Compound: 6j
Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30025344]
HepG2 IC50
4.8 μM
Compound: 6j
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30025344]
Molecular Weight

578.58

Formula

C32H40BrN3O2
CAS No.
SMILES

COC(CCC[C@]1([H])[C@]2([H])[C@]3([H])[C@@](CCCN3CCC2)([H])CN1CC(C4=C5C=CC=C4)=CN5CC6=CC=C(Br)C=C6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 147 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1472241283-11-2Anticancer agent147Anticancer agent-147FerroptosisFe2+reactive oxygen speciesROSMDAER stressliver cancerInhibitorinhibitorinhibit

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