2. Apoptosis Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Apoptosis
  4. Anticancer agent 168

Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers.

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Anticancer agent 168 Chemical Structure

Anticancer agent 168 Chemical Structure

CAS No. : 207399-56-2

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Description

Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers[1].

Molecular Weight

362.72

Formula

C16H11ClN2O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C1=CN(CC)C2=CC(Cl)=C(C3=CC=C([N+]([O-])=O)O3)C=C2C1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (27.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7569 mL 13.7847 mL 27.5695 mL
5 mM 0.5514 mL 2.7569 mL 5.5139 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7569 mL 13.7847 mL 27.5695 mL 68.9237 mL
5 mM 0.5514 mL 2.7569 mL 5.5139 mL 13.7847 mL
10 mM 0.2757 mL 1.3785 mL 2.7569 mL 6.8924 mL
15 mM 0.1838 mL 0.9190 mL 1.8380 mL 4.5949 mL
20 mM 0.1378 mL 0.6892 mL 1.3785 mL 3.4462 mL
25 mM 0.1103 mL 0.5514 mL 1.1028 mL 2.7569 mL
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Anticancer agent 168 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 168207399-56-2Anticancer agent168Anticancer agent-168DNA/RNA SynthesisApoptosisMDA-MB-231MDA-MB-468apoptosiscell-cycle arrestanticancerInhibitorinhibitorinhibit

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