2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation PI3K/Akt/mTOR
  3. Apoptosis Reactive Oxygen Species PI3K Akt
  4. Anticancer agent 235

Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116.

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Anticancer agent 235 Chemical Structure

Anticancer agent 235 Chemical Structure

CAS No. : 2411108-21-7

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Anticancer agent 235 Related Antibodies

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Description

Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116[1].

Molecular Weight

296.75

Formula

C17H13ClN2O
CAS No.
SMILES

CN1C2=NC3=CC(OC)=CC=C3C2=CC4=C1C=CC(Cl)=C4
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Anticancer agent 235 Related Classifications

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Keywords:

Anticancer agent 2352411108-21-7Anticancer agent235Anticancer agent-235ApoptosisReactive Oxygen SpeciesPI3KAktPhosphoinositide 3-kinasePKBProtein kinase Bcolorectal cancerHCT116Caco-2AGSSMMC-772HIECPANC-1Inhibitorinhibitorinhibit

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