2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. Anticancer agent 249

Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice.

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Anticancer agent 249 Chemical Structure

Anticancer agent 249 Chemical Structure

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Anticancer agent 249 Related Antibodies

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Description

Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice[1].

Molecular Weight

476.44

Formula

C25H31Cl2N3O2
SMILES

ClC1=CC=C(NC(C2CCN(CC3=CC=C(OCC4CCNCC4)C=C3)CC2)=O)C=C1Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Anticancer agent 249 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 249Anticancer agent249Anticancer agent-249HSPApoptosisHeat shock proteinstriple-negative breast cancerTNBCMCF-7PC3MM2T47DMDA-MB-231MDA-MB-468SKBr3BALB/c mouseInhibitorinhibitorinhibit

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