2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis Caspase ROS Kinase
  4. Anticancer agent 58

Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC50s of 0.6 μM and 0.7 μM, respectively. Anticancer agent 58 induces apoptosis by activating caspase 3/8/9 activity, and induces an increase of Ca2+ and ROS in cancer cells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model.

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Anticancer agent 58 Chemical Structure

Anticancer agent 58 Chemical Structure

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Anticancer agent 58 Related Antibodies

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Description

Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC50s of 0.6 μM and 0.7 μM, respectively. Anticancer agent 58 induces apoptosis by activating caspase 3/8/9 activity, and induces an increase of Ca2+ and ROS in cancer cells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model[1].

IC50 & Target

IC50: 0.6 μM in A549, 0.7 μM T24[1]
Molecular Weight

617.86

Formula

C39H55NO5
SMILES

[H][C@](CC1=CC=CC=C1)(C(O[C@H]2CC[C@]3(C(C2(C)C)CC[C@@]4(C3C(C=C5[C@]4(CC[C@]6(CC[C@](C(O)=O)(C[C@@]56[H])C)C)C)=O)C)C)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 58 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 58Anticancer agent58Anticancer agent-58ApoptosisCaspaseROS KinaseAnticancerAntitumorA549T24Xenograft modelMitochondrial membrane potentialInhibitorinhibitorinhibit

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