1. Anti-infection
  2. Parasite
  3. Antimalarial agent 39

Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents.

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Antimalarial agent 39 Chemical Structure

Antimalarial agent 39 Chemical Structure

CAS No. : 5407-57-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 31 In-stock
Solution
10 mM * 1 mL in DMSO USD 33 In-stock
Solid
25 mg USD 30 In-stock
50 mg USD 42 In-stock
100 mg USD 58 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents[1].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
63.44 μM
Compound: 16, n = 2
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 22858300]
HeLa IC50
7.22 μM
Compound: 2a
Cytotoxicity against human HeLa cells after 7 days by MTT assay
Cytotoxicity against human HeLa cells after 7 days by MTT assay
[PMID: 21489789]
L6 IC50
21.22 μM
Compound: 17a
Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis
Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis
[PMID: 24900574]
L929 CC50
< 194 μM
Compound: 5g
Cytotoxicity against mouse L929 cells after 96 hrs by alamar blue assay
Cytotoxicity against mouse L929 cells after 96 hrs by alamar blue assay
[PMID: 28215783]
Molecular Weight

221.69

Formula

C11H12ClN3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C1=C(C=C2C(=C1)C(=CC=N2)NCCN)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (56.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5108 mL 22.5540 mL 45.1080 mL
5 mM 0.9022 mL 4.5108 mL 9.0216 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 97.53%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5108 mL 22.5540 mL 45.1080 mL 112.7701 mL
5 mM 0.9022 mL 4.5108 mL 9.0216 mL 22.5540 mL
10 mM 0.4511 mL 2.2554 mL 4.5108 mL 11.2770 mL
15 mM 0.3007 mL 1.5036 mL 3.0072 mL 7.5180 mL
20 mM 0.2255 mL 1.1277 mL 2.2554 mL 5.6385 mL
25 mM 0.1804 mL 0.9022 mL 1.8043 mL 4.5108 mL
30 mM 0.1504 mL 0.7518 mL 1.5036 mL 3.7590 mL
40 mM 0.1128 mL 0.5639 mL 1.1277 mL 2.8193 mL
50 mM 0.0902 mL 0.4511 mL 0.9022 mL 2.2554 mL
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Antimalarial agent 39
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