Antimalarial agent 39

Cat. No.: HY-W131282 Purity: 97.26%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents.

For research use only. We do not sell to patients.

Antimalarial agent 39 Chemical Structure

CAS No. : 5407-57-8

Size	Price	Stock	Quantity
25 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 42	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 58	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Antimalarial agent 39 (compound 1) is an intermediate in the synthesis of antimalarial agents^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	63.44 μM Compound: 16, n = 2	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 22858300]
HeLa	IC₅₀	7.22 μM Compound: 2a	Cytotoxicity against human HeLa cells after 7 days by MTT assay Cytotoxicity against human HeLa cells after 7 days by MTT assay	[PMID: 21489789]
L6	IC₅₀	21.22 μM Compound: 17a	Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis Cytotoxicity against rat L6 cells after 72 hrs by fluorometric analysis	[PMID: 24900574]
L929	CC₅₀	< 194 μM Compound: 5g	Cytotoxicity against mouse L929 cells after 96 hrs by alamar blue assay Cytotoxicity against mouse L929 cells after 96 hrs by alamar blue assay	[PMID: 28215783]

Molecular Weight

221.69

Formula

C₁₁H₁₂ClN₃

CAS No.

5407-57-8

Appearance

Solid

Color

White to off-white

SMILES

C1=C(C=C2C(=C1)C(=CC=N2)NCCN)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (56.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5108 mL	22.5540 mL	45.1080 mL
5 mM	0.9022 mL	4.5108 mL	9.0216 mL
10 mM	0.4511 mL	2.2554 mL	4.5108 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.53%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (247 KB) HNMR (118 KB) RP-HPLC (191 KB)

Handling Instructions (2659 KB)

References

[1]. Kondaparla S, Agarwal P, Srivastava K, Puri SK, Katti SB. Design, synthesis and in vitro antiplasmodial activity of some bisquinolines against chloroquine-resistant strain. Chem Biol Drug Des. 2017 Jun;89(6):901-906. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5108 mL	22.5540 mL	45.1080 mL	112.7701 mL
	5 mM	0.9022 mL	4.5108 mL	9.0216 mL	22.5540 mL
	10 mM	0.4511 mL	2.2554 mL	4.5108 mL	11.2770 mL
	15 mM	0.3007 mL	1.5036 mL	3.0072 mL	7.5180 mL
	20 mM	0.2255 mL	1.1277 mL	2.2554 mL	5.6385 mL
	25 mM	0.1804 mL	0.9022 mL	1.8043 mL	4.5108 mL
	30 mM	0.1504 mL	0.7518 mL	1.5036 mL	3.7590 mL
	40 mM	0.1128 mL	0.5639 mL	1.1277 mL	2.8193 mL
	50 mM	0.0902 mL	0.4511 mL	0.9022 mL	2.2554 mL