2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species
  4. Antiproliferative agent-7

Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative agent-7 can increase ROS production and induce apoptosis.

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Antiproliferative agent-7 Chemical Structure

Antiproliferative agent-7 Chemical Structure

CAS No. : 2497687-47-3

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Antiproliferative agent-7 Related Antibodies

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Description

Antiproliferative agent-7 (compound 8f) is a potent anti-proliferative agent. Antiproliferative agent-7 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC50s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative agent-7 can increase ROS production and induce apoptosis[1].

IC50 & Target

IC50: 3.5 μM (MCF-7), 15.54 μM (MDA-MB-231), 30.43 μM (HCT-116), 34.8 μM (FR-2)[1]
Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
30.43 μM
Compound: 8f
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 32947093]
MCF7 IC50
3.5 μM
Compound: 8f
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 32947093]
MDA-MB-231 IC50
15.54 μM
Compound: 8f
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by SRB assay
[PMID: 32947093]
Molecular Weight

440.58

Formula

C28H32N4O
CAS No.
SMILES

CCN(CC)CCCOC1=CC=C(C2=C(C3=CC=CC=C3)N=NN2CC4=CC=CC=C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-72497687-47-3Antiproliferative agent7Antiproliferative agent 7ApoptosisReactive Oxygen SpeciesAntiproliferativeMCF-7MDA-MB-231HCT-116FR-2Inhibitorinhibitorinhibit

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