2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. Antitumor agent-127

Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Antitumor agent-127 Chemical Structure

Antitumor agent-127 Chemical Structure

Size Price Stock Quantity
5 mg USD 200 In-stock
10 mg USD 320 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Antitumor agent-127 Related Antibodies

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Description

Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines[1].

In Vitro

Antitumor agent-127 (compound 1) dose not induce apoptosis in Mia PaCa-2 cells, a model pancreatic tumor cell line with a relatively low level of cell surface expression of ROR1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-127 Related Antibodies
Molecular Weight

1670.92

Formula

C86H107N15O18S
Appearance

Solid

Color

White to off-white

Sequence Shortening

Ac-FYLVYSGWY-N(Me)Phe-LCG-NH2 (thioether bridge:Phe1-Cys12)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (59.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5985 mL 2.9924 mL 5.9847 mL
5 mM 0.1197 mL 0.5985 mL 1.1969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5985 mL 2.9924 mL 5.9847 mL 14.9618 mL
5 mM 0.1197 mL 0.5985 mL 1.1969 mL 2.9924 mL
10 mM 0.0598 mL 0.2992 mL 0.5985 mL 1.4962 mL
15 mM 0.0399 mL 0.1995 mL 0.3990 mL 0.9975 mL
20 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7481 mL
25 mM 0.0239 mL 0.1197 mL 0.2394 mL 0.5985 mL
30 mM 0.0199 mL 0.0997 mL 0.1995 mL 0.4987 mL
40 mM 0.0150 mL 0.0748 mL 0.1496 mL 0.3740 mL
50 mM 0.0120 mL 0.0598 mL 0.1197 mL 0.2992 mL
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Antitumor agent-127 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-127Antitumor agent127Antitumor agent 127RORRAR-related orphan receptor786-OMDA-MB-231Inhibitorinhibitorinhibit

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