2. One-stop Drug Screening
  3. Screening Libraries
  4. Bioactive Compound Series
  5. According to Structures
  6. Macrocyclic Compound Library
Macrocyclic Compound Library

Cat. No.: HY-L041

Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity.

MCE offers a unique collection of 394 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

  • 96-well Plate with Peelable Foil Seal
- +
Contact Us for Customization

Compound Screening Libraries

Download
Related Products
Recommendation

Top Publications Citing Use of MedChemExpress (MCE) Products

View More

Publications Citing Use of MedChemExpress (MCE) Products

  • Biological Activity
  • Product Details
  • Composition

Description & Advantages

•   A unique collection of 394 macrocyclic compounds that for drug discovery.

•   A useful tool for the discovery of "undruggable" targets such as protein-protein interactions (PPIs) inhibitors.

•   Cyclopeptides, crown ethers, calixarene and so on are included.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

Product Details

Formulation:

A collection of 394 macrocyclic compounds supplied as Solid

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96-well Storage Tubes with Rack

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

HCV (9)

HIV (9)

mTOR (9)

HSP (7)

CXCR (6)

FKBP (6)

Ras (4)

ERK (3)

FLT3 (3)

HSV (3)

PI3K (3)

PKC (3)

Akt (2)

CDK (2)

COX (2)

EGFR (2)

FAP (2)

GHSR (2)

JAK (2)

MMP (2)

STAT (2)

YAP (2)

BCRP (1)

Related Service
Recommendation
Compound Customization
  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
  •  YES
Contact Us for Customization

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Container *

    Remarks

    Inquiry Information

    Product Name:
    Macrocyclic Compound Library
    Cat. No.:
    HY-L041
    Quantity:
    MCE Japan Authorized Agent:

    Request SDF File

    Please enter your email address. We will send your requested SDF file to you as soon as possible.

    • 96-well Plate with Peelable Foil Seal
    • 96-well Plate with Peelable Foil Seal

    Request for SDF File

    Please fill out this form to request the SDF file. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Applicant Name *

    Email Address *

    		 

    Organization Name *

    Phone Number

    		     

    Remarks

    Request for SDF File

    We have received your request and will respond to you as soon as possible.