2. JAK/STAT Signaling Stem Cell/Wnt Metabolic Enzyme/Protease
  3. STAT Quinone Reductase
  4. Antitumor agent-195

Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model.

For research use only. We do not sell to patients.

Antitumor agent-195 Chemical Structure

Antitumor agent-195 Chemical Structure

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Antitumor agent-195 Related Antibodies

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Description

Antitumor agent-195 (compound 16c) is a dual targeting agent of STAT3 and NQO1. Antitumor agent-195 significantly inhibits phosphorylation of STAT3 at Tyr705 at a concentration of 1 μM and effectively induce Apoptosis in MDAMB-231 and MDA-MB-468 breast cancer cells. Antitumor agent-195 as a NQO1 substrate strongly increases ROS generation and causes severe DNA damage in a dose-dependent manner. Antitumor agent-195 shows encouraging anti-tumor efficacy in the MDA-MB-231 xenograft model[1].

IC50 & Target[1]

STAT3

0.52 μM (IC50)

NQO1

1.48 μM (IC50)

Molecular Weight

378.42

Formula

C22H22N2O4
SMILES

O=C(C1=C(C2=C3C4=C(C(N(CCN5CCCCC5)CC4)=O)O2)C=CC=C1)C3=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Antitumor agent-195 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-195Antitumor agent195Antitumor agent 195STATQuinone Reductasebreast canceranti-tumoranti-proliferativeMDA-MB-231 cellsMDA-MB-468 cellsDNA damageInhibitorinhibitorinhibit

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