2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Apalutamide-d4

Apalutamide-d4  (Synonyms: ARN-509-d4)

Cat. No.: HY-16060S Purity: 99.90%
COA Handling Instructions

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Apalutamide-d4 is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

For research use only. We do not sell to patients.

Apalutamide-d<sub>4</sub> Chemical Structure

Apalutamide-d4 Chemical Structure

CAS No. : 1638885-65-0

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1 mg USD 420 In-stock
5 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Apalutamide-d4:

Apalutamide-d4 Related Antibodies

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Description

Apalutamide-d4 is a deuterium labeled Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

Molecular Weight

481.46

Formula

C21H11D4F4N5O2S
CAS No.
Unlabeled CAS

956104-40-8
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43C([2H])([2H])CC4([2H])[2H])C=C1F
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (103.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0770 mL 10.3851 mL 20.7702 mL
5 mM 0.4154 mL 2.0770 mL 4.1540 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

COA (254 KB) HNMR (116 KB) RP-HPLC (179 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.0770 mL 10.3851 mL 20.7702 mL 51.9254 mL
5 mM 0.4154 mL 2.0770 mL 4.1540 mL 10.3851 mL
10 mM 0.2077 mL 1.0385 mL 2.0770 mL 5.1925 mL
15 mM 0.1385 mL 0.6923 mL 1.3847 mL 3.4617 mL
20 mM 0.1039 mL 0.5193 mL 1.0385 mL 2.5963 mL
25 mM 0.0831 mL 0.4154 mL 0.8308 mL 2.0770 mL
30 mM 0.0692 mL 0.3462 mL 0.6923 mL 1.7308 mL
40 mM 0.0519 mL 0.2596 mL 0.5193 mL 1.2981 mL
50 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0385 mL
60 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8654 mL
80 mM 0.0260 mL 0.1298 mL 0.2596 mL 0.6491 mL
100 mM 0.0208 mL 0.1039 mL 0.2077 mL 0.5193 mL
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Apalutamide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apalutamide-d41638885-65-0ARN-509-d4Androgen ReceptorInhibitorinhibitorinhibit

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