APC 366 TFA

Cat. No.: HY-105999B: FAQs
Data Sheet SDS COA Handling Instructions

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APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases.

For research use only. We do not sell to patients.

APC 366 TFA Chemical Structure

CAS No. : 2421110-28-1

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1 mg	USD 110	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of APC 366 TFA:

APC 366 Get quote
APC 366 hydrochloride Get quote

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Description

APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases^[1].

IC₅₀ & Target

mast cell tryptase^[1]

In Vivo

APC 366 (TFA) (5 mg/kg/0.1 ml; s.c.) reduces the eosinophil recruitment induced by PAR-2 activating peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice (18–25 g)^[1]
Dosage:	5 mg/kg/0.1 ml
Administration:	S.c.
Result:	Reduced the eosinophil recruitment induced by PAR-2 activating peptide.

Molecular Weight

554.52

Formula

C₂₄H₂₉F₃N₆O₆

CAS No.

2421110-28-1

Appearance

Solid

Color

White to off-white

SMILES

OC(C(F)(F)F)=O.OC1=C(C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N)=O)=O)=O)C=CC3=C1C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Matos NA, et al. Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2. Inflammation. 2013;36(6):1260-1267. [Content Brief]

APC 366 TFA Related Classifications

Others

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APC 3662421110-28-1APC366APC-366OthersirreversiblemasttryptaseallergiceosinophilrecruitmentPAR-2Inhibitorinhibitorinhibit

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