2. Anti-infection GPCR/G Protein
  3. Apelin Receptor (APJ) HIV
  4. Apelin-12

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Apelin-12 Chemical Structure

Apelin-12 Chemical Structure

CAS No. : 229961-08-4

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5 mg USD 350 In-stock
10 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Apelin-12 Related Antibodies

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Description

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].

IC50 & Target

HIV-1

 

In Vitro

Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1].
Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2].
Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apelin-12 Related Antibodies
Molecular Weight

1422.70

Formula

C64H103N21O14S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

RPRLSHKGPMPF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (70.29 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7029 mL 3.5144 mL 7.0289 mL
5 mM 0.1406 mL 0.7029 mL 1.4058 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

SDS (252 KB)

COA (253 KB) LCMS (89 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7029 mL 3.5144 mL 7.0289 mL 17.5722 mL
5 mM 0.1406 mL 0.7029 mL 1.4058 mL 3.5144 mL
10 mM 0.0703 mL 0.3514 mL 0.7029 mL 1.7572 mL
15 mM 0.0469 mL 0.2343 mL 0.4686 mL 1.1715 mL
20 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8786 mL
25 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7029 mL
30 mM 0.0234 mL 0.1171 mL 0.2343 mL 0.5857 mL
40 mM 0.0176 mL 0.0879 mL 0.1757 mL 0.4393 mL
50 mM 0.0141 mL 0.0703 mL 0.1406 mL 0.3514 mL
60 mM 0.0117 mL 0.0586 mL 0.1171 mL 0.2929 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Apelin-12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apelin-12229961-08-4Apelin12Apelin 12Apelin Receptor (APJ)HIVHuman immunodeficiency virusorphanreceptorbodyfluidhomeostasisneuroprotectivehistamineacidsecretionInhibitorinhibitorinhibit

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