Apicularen B

Cat. No.: HY-N12413: Data Sheet Handling Instructions Technical Support

Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis.

For research use only. We do not sell to patients.

Apicularen B Chemical Structure

CAS No. : 220757-06-2

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Description	Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis^[1]^[2].
Molecular Weight	644.71
Formula	C₃₃H₄₄N₂O₁₁
CAS No.	220757-06-2
SMILES	O=C(O[C@H]1C/C=C/NC(/C=C\C=C/CC)=O)C(C(C[C@@](O[C@@]2([H])C1)([H])C[C@H](C2)O[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@@H]3O)O)NC(C)=O)=CC=C4)=C4O
Structure Classification	Others
Initial Source	Microorganisms Chondromyces
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Köteles I, et al. Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. Molecules. 2020 Sep 2;25(17):4009. [Content Brief] [2]. Hong J, et al. Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Lett. 2006 May 15;580(11):2723-30. [Content Brief]

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Keywords:

Apicularen B220757-06-2Proton PumpRAW 264.7Archangium gephyraOsteopetrosisInhibitorinhibitorinhibit

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Apicularen B

Biological Activity

Purity & Documentation

References

Customer Review

Apicularen B Related Classifications

Molarity Calculator

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