2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Apitegromab

Apitegromab  (Synonyms: SRK-015)

Cat. No.: HY-P99441 Purity: 99.51%
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Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody.

For research use only. We do not sell to patients.

CAS No. : 2278276-46-1

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Description

Apitegromab (SRK-015) is an anti-promyostatin monoclonal antibody. Apitegromab can be used for the research of neuromuscular disease including spinal muscular atrophy[1][2]. In Vitro:Apitegromab (IC50: Human 286 nM, Cynomolgus 626 nM, Rat 178 nM, 16 h) effectively inhibits promyostatin activation, with species-dependent potency differences[2]. In Vivo:Apitegromab (10-300 mg/kg, i.v., once weekly for 4, 7, or 26 weeks) was well-tolerated in juvenile and adult Sprague Dawley rats as well as adult cynomolgus monkeys, with no severe toxicological effects[2].

Isotype

Human IgG4 lambda
Species

Human
Parmacokinetics
Species Dose Route Indicator value
Rat 10mg/kg i.v. Cmax 213μg/mL
Rat 10mg/kg i.v. AUC0-t 16200μg·h/mL
Rat 30mg/kg i.v. AUC0-∞ 51100μg·h/mL
Rat 100mg/kg i.v. AUC0-t 170000μg·h/mL
Cynomolgus Monkey 10mg/kg i.v. Cmax 369μg/mL
Cynomolgus Monkey 30mg/kg i.v. Cmax 876μg/mL
Cynomolgus Monkey 100mg/kg i.v. Cmax 2560μg/mL
Rat 30mg/kg i.v. Cmax 695μg/mL
Rat 100mg/kg i.v. Cmax 2360μg/mL
Cynomolgus Monkey 10mg/kg i.v. Tmax 1hr
Cynomolgus Monkey 30mg/kg i.v. Tmax 1hr
Cynomolgus Monkey 100mg/kg i.v. Tmax 1hr
Rat 10mg/kg i.v. Tmax 1.0hr
Rat 30mg/kg i.v. Tmax 1hr
Rat 100mg/kg i.v. Tmax 1hr
Cynomolgus Monkey 10mg/kg i.v. AUC0-t 30400μg·h/mL
Cynomolgus Monkey 30mg/kg i.v. AUC0-t 77200μg·h/mL
Cynomolgus Monkey 100mg/kg i.v. AUC0-t 240000μg·h/mL
In Vivo
Animal Model: Adult cynomolgus monkeys (32-48 months)[2]
Dosage: 10, 30, 100 mg/kg
Administration: Intravenous bolus (IV bolus), once weekly for 4 weeks
Result: Did not cause treatment-related adverse effects, increased gastrocnemius and biceps brachii mass (5-25%), but did not exhibit dose dependency, and did not lead to significant histopathological changes or cardiac electrophysiological abnormalities.
Animal Model: Sprague Dawley rats: adult group (6-8 weeks) or juvenile group (postnatal day 21)[2]
Dosage: 10, 30, 100, 300 mg/kg
Administration: Intravenous bolus (IV bolus), once weekly for 4 weeks (adult group), 7 weeks (juvenile group) or 26 weeks (adult group)
Result: Increased body weight independently of food intake, enhanced skeletal muscle mass (biceps brachii and gastrocnemius) by 3-32%, and caused minor clinical chemistry changes (mild increase in total protein and globulin), which were mostly reversible (adult group, administration for 4 weeks).
increased muscle mass by 15-33%, induced mild muscle fiber hypertrophy (histological analysis), and caused minor hematological changes without significant toxicity; it did not produce adverse effects on cardiovascular, neurological, or reproductive systems (adult group, administration for 26 weeks).
increased body weight (significant in females) without impacting growth and development, enhanced skeletal muscle mass (biceps brachii and gastrocnemius) by 13-28%, and did not cause neurobehavioral abnormalities (acoustic startle, locomotor activity, Morris water maze); it had no effects on sperm quality or fertility, indicating normal reproductive function (juvenile group).
Clinical Trial
Molecular Weight

145060.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Apitegromab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 lambda
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apitegromab2278276-46-1SRK-015SRK015SRK 015TGF-beta/SmadTransforming growth factor betamonoclonal antibodyanti-promyostatinneuromuscular diseasespinal muscular atrophyInhibitorinhibitorinhibit

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