2. PI3K/Akt/mTOR Apoptosis
  3. Akt PI3K Apoptosis
  4. Apoptin-derived peptide

Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer.

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Apoptin-derived peptide Chemical Structure

Apoptin-derived peptide Chemical Structure

CAS No. : 2232156-31-7

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Apoptin-derived peptide Related Antibodies

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Akt Akt1 Akt2 Akt3

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer[1].

In Vitro

Apoptin-derived peptide (40-100 μg/mL, 24 h) promotes ARNT down-regulation by inhibiting the PI3K/AKT signaling pathway to reverse CDDP resistance in SGC-7901/CDDP cells[1].
Apoptin-derived peptide (10-30 μg/mL, 24 h) inhibits the migration and invasion in SGC-7901, SGC-7901/CDDP and MGC-803 cells[1].
Apoptin-derived peptide (30-60 μg/mL, 24 h) increases the CDDP sensitivity of SGC-7901/CDDP cells[1].
Apoptin-derived peptide (10-20 μg/mL, 24 h) increases the G2/M phase population and induces apoptosis in SGC-7901 and SGC-7901/CDDP cells.[1].
Apoptin-derived peptide (10-70 μg/mL, 4-24 h) has an excellent inhibitory effect in SGC-7901 and SGC-7901/CDDP cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptin-derived peptide Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293, SGC-7901, SGC-7901/CDDP
Concentration: 10 μg/mL, 20 μg/mL, 30 μg/mL, 40 μg/mL, 50 μg/mL, 60 μg/mL, 70 μg/mL
Incubation Time: 4 h, 6 h, 8 h, 12 h, 18 h, 24 h
Result: Produced large effects in both SGC-7901 and SGC-7901/CDDP cells at 60 μg/mL for 6 h and had no obvious effect on HEK293 cells.

Apoptosis Analysis[1]

Cell Line: SGC-7901, SGC-7901/CDDP
Concentration: 30 μg/mL, 60 μg/mL
Incubation Time: 24 h
Result: Induced SGC-7901 cell apoptosis in a concentration dependent manner.
Induced considerable apoptotic cell death in SGC-7901/CDDP cells in a strong time- and dose-dependent fashion.

Cell Cycle Analysis[1]

Cell Line: SGC-7901, SGC-7901/CDDP
Concentration: 10 μg/mL, 20 μg/mL
Incubation Time: 24 h
Result: Increase the G2/M phase population.

Cell Invasion Assay[1]

Cell Line: SGC-7901, SGC-7901/CDDP, MGC-803
Concentration: 10 μg/mL, 20 μg/mL, 30 μg/mL
Incubation Time: 48 h
Result: Significantly reduced the number of invasive cells.

Cell Migration Assay [1]

Cell Line: SGC-7901, SGC-7901/CDDP, MGC-803
Concentration: 10 μg/mL, 20 μg/mL, 30 μg/mL
Incubation Time: 48 h
Result: Effectively inhibited the migration ability of MGC-803, SGC-7901, and SGC-7901/CDDP cells in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: SGC-7901, SGC-7901/CDDP
Concentration: 40 μg/mL, 60 μg/mL, 80 μg/mL, 100 μg/mL
Incubation Time: 24 h
Result: Significantly down-regulated the phosphorylation of p85 (p-p85) and AKT (p-AKT) proteins at concentrations from 40 μg/mL to 100 μg/mL.
Down-regulated the expression of MDR1 and ARTN in Apoptin-derived peptide-treated SGC-7901/CDDP cells.
Notably decreased p85 and AKT activities.
Molecular Weight

5177.33

Formula

C223H417N89O50S
CAS No.
Sequence

Met-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Pro-Pro-Ser-Lys-Lys-Arg-Ile-Arg-Ile-Gly-Ile-Ala-Gly-Ile-Thr-Ile-Thr-Leu-Ser-Leu-Arg-Pro-Arg-Thr-Ala-Lys-Arg-Arg-Ile-Arg-Leu
Sequence Shortening

MGRKKRRQRRRKPPSKKRIRIGIAGITITLSLRPRTAKRRIRL
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptin-derived peptide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptin-derived peptide2232156-31-7AktPI3KApoptosisPKBProtein kinase BPhosphoinositide 3-kinaseSGC-7901SGC-7901/CDDPMGC-803SW-620U87-MGU251-MGHEK293Inhibitorinhibitorinhibit

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