2. Membrane Transporter/Ion Channel Apoptosis
  3. ATP Synthase Apoptosis
  4. Apoptolidin

Apoptolidin is a polyketide isolated from Nocardiopsis?bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells.

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Apoptolidin Chemical Structure

Apoptolidin Chemical Structure

CAS No. : 194874-06-1

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Apoptolidin Related Antibodies

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Description

Apoptolidin is a polyketide isolated from Nocardiopsis?bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

Cellular Effect
Cell Line Type Value Description References
NCI-H292 EC50
< 50 nM
Compound: 228
Cytotoxicity against human NCI-H292 cells assessed as reduction in cell viability incubated for 4 days by WST-1 assay
Cytotoxicity against human NCI-H292 cells assessed as reduction in cell viability incubated for 4 days by WST-1 assay
[PMID: 29126728]
NCI-H292 IC50
32 μM
Compound: Apoptolidin A
Anticancer activity against human NCI-H292 cells assessed as reduction in cell proliferation incubated for 48 hrs by Calcein AM and Pluronic F-127 staining based fluorescence plate reader analysis
Anticancer activity against human NCI-H292 cells assessed as reduction in cell proliferation incubated for 48 hrs by Calcein AM and Pluronic F-127 staining based fluorescence plate reader analysis
[PMID: 32942072]
In Vitro

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptolidin Related Antibodies
Molecular Weight

1129.37

Formula

C58H96O21
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@](OC(/C(C)=C/C(C)=C/C(C)=C/[C@H]1C)=O)([H])C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H](O[C@H]2C)[C@H]([C@@H]([C@H]2OC)O)O)C)O)OC)[C@](O[C@@H]([C@@H]3C)C[C@H](COC)O[C@H](O[C@H]4C)C[C@](O)([C@H]4O[C@H](O[C@@H]5C)C[C@H]([C@@H]5O)OC)C)([C@@H]([C@H]3O)C)O
Structure Classification
Initial Source

Nocardiopsis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (0.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation

Purity: 95.6%

SDS (251 KB)

COA (255 KB)

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Apoptolidin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptolidin194874-06-1ATP SynthaseApoptosispolyketideF0F1-ATPasecancerapoptoticRG-E1A-7RG-E1A19K-2RG-E1A54K-9RG-E1-4Inhibitorinhibitorinhibit

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