1. GPCR/G Protein
  2. GLP Receptor
  3. Apraglutide TFA

Apraglutide TFA  (Synonyms: FE 203799 TFA)

Cat. No.: HY-P1714A Purity: 98.01%
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Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Apraglutide TFA Chemical Structure

Apraglutide TFA Chemical Structure

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1 mg USD 120 In-stock
5 mg USD 330 In-stock
10 mg USD 520 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].

In Vivo

Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NewbornDuroc piglets, 2-5 days old and weighing between 2-2.6 kg[1].
Dosage: 5 mg/kg/dose.
Administration: Subcutaneously, twice on days 0 and 4 postsurgery.
Result: On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.
Clinical Trial
Molecular Weight

3765.25 (free base)

Formula

C172H263N43O52.xC2HF3O2

Appearance

Solid

Color

White to off-white

Sequence

His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-{Nle}-{d-Phe}-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH2

Sequence Shortening

HGDGSFSDE-{Nle}-{d-Phe}-TILDLLAARDFINWLIQTKITD-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 66.67 mg/mL (ultrasonic and adjust pH to 11 with NaOH)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.01%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Apraglutide TFA
Cat. No.:
HY-P1714A
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