2. GPCR/G Protein
  3. GLP Receptor
  4. Apraglutide TFA

Apraglutide TFA  (Synonyms: FE 203799 TFA)

Cat. No.: HY-P1714A Purity: 98.01%
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Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum.

For research use only. We do not sell to patients.

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Apraglutide TFA Chemical Structure

Apraglutide TFA Chemical Structure

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1 mg USD 120 In-stock
5 mg USD 330 In-stock
10 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

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Apraglutide TFA Related Antibodies

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Description

Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].

In Vivo

Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NewbornDuroc piglets, 2-5 days old and weighing between 2-2.6 kg[1].
Dosage: 5 mg/kg/dose.
Administration: Subcutaneously, twice on days 0 and 4 postsurgery.
Result: On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.
Clinical Trial
Molecular Weight

3765.25 (free base)

Formula

C172H263N43O52.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-{Nle}-{d-Phe}-Thr-Ile-Leu-Asp-Leu-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-NH2
Sequence Shortening

HGDGSFSDE-{Nle}-{d-Phe}-TILDLLAARDFINWLIQTKITD-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 66.67 mg/mL (ultrasonic and adjust pH to 11 with NaOH)

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.01%

COA (240 KB) RP-HPLC (111 KB) MS (191 KB)

Handling Instructions (2659 KB)
References
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Apraglutide TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ApraglutideFE 203799FE203799FE-203799GLP ReceptorInhibitorinhibitorinhibit

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