2. Others GPCR/G Protein
  3. Isotope-Labeled Compounds Endothelin Receptor
  4. Aprocitentan-d4

Aprocitentan-d4  (Synonyms: ACT-132577 d4)

Cat. No.: HY-15895S Purity: 97.39%
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Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

For research use only. We do not sell to patients.

Aprocitentan-d<sub>4</sub> Chemical Structure

Aprocitentan-d4 Chemical Structure

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1 mg USD 450 In-stock
5 mg USD 1450 In-stock
10 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Aprocitentan-d4:

Aprocitentan-d4 Related Antibodies

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ETA ETB

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Description

Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

IC50 & Target[1]

ETA

3.4 nM (IC50)

ETA

6.7 (pA2)

ETB

987 nM (IC50)

ETB

5.5 (pA2)

Molecular Weight

550.22

Formula

C16H10D4Br2N6O4S
Unlabeled CAS

1103522-45-7
Appearance

Solid

Color

White to off-white

SMILES

O=S(N)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (45.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 25 mg/mL (45.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8175 mL 9.0873 mL 18.1745 mL
5 mM 0.3635 mL 1.8175 mL 3.6349 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.8175 mL 9.0873 mL 18.1745 mL 45.4364 mL
5 mM 0.3635 mL 1.8175 mL 3.6349 mL 9.0873 mL
10 mM 0.1817 mL 0.9087 mL 1.8175 mL 4.5436 mL
15 mM 0.1212 mL 0.6058 mL 1.2116 mL 3.0291 mL
20 mM 0.0909 mL 0.4544 mL 0.9087 mL 2.2718 mL
25 mM 0.0727 mL 0.3635 mL 0.7270 mL 1.8175 mL
30 mM 0.0606 mL 0.3029 mL 0.6058 mL 1.5145 mL
40 mM 0.0454 mL 0.2272 mL 0.4544 mL 1.1359 mL
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Aprocitentan-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aprocitentan-d4ACT-132577 d4Isotope-Labeled CompoundsEndothelin ReceptorDeuteriumlabeledETAETBpharmacologicallymetaboliteMacitentanInhibitorinhibitorinhibit

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