2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. Apstatin

Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection.

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Apstatin Chemical Structure

Apstatin Chemical Structure

CAS No. : 160470-73-5

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Apstatin Related Antibodies

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Description

Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection[1][2].

IC50 & Target

IC50: 2.6 µM (rat APP); 0.64 µM (human APP)[1]
In Vivo

Apstatin (1 mg/kg; i.v.; 5 min before ischaemia) reduces myocardial infarct size (IS) in acute myocardial ischaemia model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 270-310 g, Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: I.v.; 5 min before ischaemia
Result: Significantly reduced infarct size (IS) in acute myocardial ischaemia.
Molecular Weight

459.54

Formula

C23H33N5O5
CAS No.
SMILES

C[C@@H](C(N)=O)NC([C@H]1N(C([C@H]2N(C([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)CCC2)=O)CCC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apstatin Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apstatin160470-73-5Aminopeptidasemyocardial infarct sizecardioprotectionInhibitorinhibitorinhibit

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