2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. Apstatin TFA

Apstatin TFA is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin TFA shows cardioprotection.

For research use only. We do not sell to patients.

Apstatin TFA Chemical Structure

Apstatin TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Apstatin TFA:

Apstatin TFA Related Antibodies

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  • Purity & Documentation

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Description

Apstatin TFA is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin TFA shows cardioprotection[1][2].

In Vivo

Apstatin (1 mg/kg; i.v.; 5 min before ischaemia) TFA reduces myocardial infarct size (IS) in acute myocardial ischaemia model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 270-310 g, Male Wistar rats[1]
Dosage: 1 mg/kg
Administration: I.v.; 5 min before ischaemia
Result: Significantly reduced infarct size (IS) in acute myocardial ischaemia.
Molecular Weight

573.56

Formula

C25H34F3N5O7
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](C(N)=O)NC([C@H]1N(C([C@H]2N(C([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)CCC2)=O)CCC1)=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (217.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7435 mL 8.7175 mL 17.4350 mL
5 mM 0.3487 mL 1.7435 mL 3.4870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7435 mL 8.7175 mL 17.4350 mL 43.5874 mL
5 mM 0.3487 mL 1.7435 mL 3.4870 mL 8.7175 mL
10 mM 0.1743 mL 0.8717 mL 1.7435 mL 4.3587 mL
15 mM 0.1162 mL 0.5812 mL 1.1623 mL 2.9058 mL
20 mM 0.0872 mL 0.4359 mL 0.8717 mL 2.1794 mL
25 mM 0.0697 mL 0.3487 mL 0.6974 mL 1.7435 mL
30 mM 0.0581 mL 0.2906 mL 0.5812 mL 1.4529 mL
40 mM 0.0436 mL 0.2179 mL 0.4359 mL 1.0897 mL
50 mM 0.0349 mL 0.1743 mL 0.3487 mL 0.8717 mL
60 mM 0.0291 mL 0.1453 mL 0.2906 mL 0.7265 mL
80 mM 0.0218 mL 0.1090 mL 0.2179 mL 0.5448 mL
100 mM 0.0174 mL 0.0872 mL 0.1743 mL 0.4359 mL
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Apstatin TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ApstatinAminopeptidaseAPP Inhibitormyocardial infarct sizecardioprotectionInhibitorinhibitorinhibit

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