Aristolactam A IIIa (Synonyms: Aristololactam A IIIa; Sch 546909)

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Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells.

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Aristolactam A IIIa Chemical Structure

CAS No. : 97399-91-2

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DYRK1 DYRK2 DYRK3 DYRK4

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	> 10 nM Compound: SCH-546909	Antiproliferative activity against human MCF7 cells by soft agar growth assay Antiproliferative activity against human MCF7 cells by soft agar growth assay	[PMID: 20097066]
MCF7	IC₅₀	3 μM Compound: SCH-546909	Antiproliferative activity against human MCF7 cells by clonogenicity assay Antiproliferative activity against human MCF7 cells by clonogenicity assay	[PMID: 20097066]

Molecular Weight

281.26

Formula

C₁₆H₁₁NO₄

CAS No.

97399-91-2

SMILES

O=C1NC2=C3C1=CC(O)=C(OC)C3=C4C(C=CC(O)=C4)=C2

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chia YC, et al. Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. J Nat Prod. 2000 Aug;63(8):1160-3. [Content Brief]

Aristolactam A IIIa Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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