ARN24139

Cat. No.: HY-148719: FAQs
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ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC₅₀ of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo.

For research use only. We do not sell to patients.

ARN24139 Chemical Structure

CAS No. : 2699768-78-8

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Topoisomerase Topo I Topo II

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Description

ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC₅₀ of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo^[1].

In Vitro

ARN24139(compound 3f) has antiproliferative activity on DU145, HeLa and A549 cells with the IC₅₀ values of 4.7, 3.8 and 3.1μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The pharmacokinetic parameters of ARN24139(compound 3f) in mice

Parameter	IV (3 mg/kg)	PO (10 mg/kg)
C_max(ng/mL)	7366	428
T_max(min)	5	120
AUC_plasma(min*ng/mL)	295528	77385
t_1/2(min)	30	190
Vd(L/kg)	3	18
CL(L/min/kg)	0.004	-
F(%)	8	8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.46

Formula

C₂₄H₁₆F₃N₃O₄S

CAS No.

2699768-78-8

SMILES

O=C(C1C(N(C(N(C2=CC=CC=C2)C1=O)=S)C3=CC=CC=C3)=O)NC4=CC(OC(F)(F)F)=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jose M Arencibia, et al. Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity. J Med Chem. 2020 Apr 9;63(7):3508-3521. [Content Brief]

ARN24139 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARN241392699768-78-8ARN 24139ARN-24139TopoisomerasetopoIItopoisomerase IIcancerproliferationInhibitorinhibitorinhibit

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