2. Anti-infection
  3. Filovirus
  4. As-358

As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM.

For research use only. We do not sell to patients.

As-358 Chemical Structure

As-358 Chemical Structure

CAS No. : 2222042-47-7

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Other Forms of As-358:

As-358 Related Antibodies

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EBOV MARV ZEBOV

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Description

As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM[1].

IC50 & Target

EBOV

 

MARV

 

Cellular Effect
Cell Line Type Value Description References
HEK293 CC50
302 μM
Compound: 4
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 30108738]
HEK-293T CC50
289.7 μM
Compound: 3b; As-358
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay
[PMID: 32905862]
MDCK CC50
69.6 μM
Compound: 14
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
[PMID: 30108810]
Vero CC50
442.9 μM
Compound: 3b; As-358
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis
[PMID: 32905862]
In Vitro

As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV[1].
As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC50s of 1.7 and 2.2 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

As-358 Related Antibodies

Cell Proliferation Assay

Cell Line: Vero (infected with EBOV and MARV)[1]
Concentration: 0-500 μM
Incubation Time: 10 days
Result: Exhibited inhibitory activities against EBOV and MARV, with IC50s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.
Molecular Weight

293.44

Formula

C18H31NO2
CAS No.
SMILES

O=C(O[C@@H]1C[C@@H]2CC[C@]1(C2(C)C)C)CCN3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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As-358 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

As-3582222042-47-7As358As 358FilovirusEbola virusMarburg virusAntiviralSelectiveInhibitorinhibitorinhibit

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HY-146883
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