ASK1-IN-3

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ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC₅₀ of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities.

For research use only. We do not sell to patients.

ASK1-IN-3 Chemical Structure

CAS No. : 2426705-19-1

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

ASK1

33.8 nM (IC₅₀)

In Vitro

ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis^[1].
ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis

Cell Line:	HepG2^[1]
Concentration:	10, 20 and 50 μM
Incubation Time:	48 hours
Result:	Induced PARP cleavage in a dose dependent manner.

Cell Cycle Analysis

Cell Line:	HepG2^[1]
Concentration:	1, 2, 4, 8, and 16 μM
Incubation Time:	24 hours
Result:	Significantly arrested cycle progression at G1 phase.

Molecular Weight

378.39

Formula

C₁₈H₁₈N₈O₂

CAS No.

2426705-19-1

SMILES

C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277. [Content Brief]

ASK1-IN-3 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASK1-IN-32426705-19-1MAP3KApoptosisMAP kinase kinase kinase, MEKK, MAPKKKASKCell cycleCancerNonalcoholic steatohepatitisHepG2Inhibitorinhibitorinhibit

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