2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR DNA-PK PI3K
  4. ATR-IN-15

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively.

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ATR-IN-15 Chemical Structure

ATR-IN-15 Chemical Structure

CAS No. : 2756665-52-6

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ATR-IN-15 Related Antibodies

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ATM ATR

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].

IC50 & Target

ATR

8 nM (IC50)

PI3K

5131 nM (IC50)

ATM

> 10000 nM (IC50)

Molecular Weight

378.43

Formula

C19H22N8O
CAS No.
SMILES

CC1=NC(C2=CC=NN2)=C3N=C(C=C(N13)N4[C@H](C)COCC4)C5=CC=NN5C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATR-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATR-IN-152756665-52-6ATM/ATRDNA-PKPI3KAtaxia telangiectasia mutatedATM and RAD3 relatedDNA-dependent protein kinasePhosphoinositide 3-kinaseorally activecolon tumorLoVo cellsInhibitorinhibitorinhibit

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