2. Apoptosis MAPK/ERK Pathway GPCR/G Protein Stem Cell/Wnt Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Ras Raf MEK ERK Caspase PARP Bcl-2 Family
  4. ATWLPPRAANLLMAAS

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis..

For research use only. We do not sell to patients.

ATWLPPRAANLLMAAS Chemical Structure

ATWLPPRAANLLMAAS Chemical Structure

CAS No. : 1228447-26-4

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ATWLPPRAANLLMAAS Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis.[1][2].

In Vitro

ATWLPPRAANLLMAAS (V3) (25-200 μM; 12-24 h) can inhibit the proliferation, viability, migration and invasion of human HCC (SMMC-7721, Huh-7) cells by inhibiting the Ras/Raf/MEK/ERK signaling pathway, however, no significant effect was observed in HL-7702 cells[2].
ATWLPPRAANLLMAAS (200 µM; 24 h) increases apoptosis and decreases protein levels of H-RAS, phosphorylated (p)-RAF, p-MEK, and p-extracellular signal-regulated protein kinase (ERK) in human HCC (SMMC-7721, Huh-7) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATWLPPRAANLLMAAS Related Antibodies

Cell Migration Assay [2]

Cell Line: HL-7702, SMMC-7721, Huh-7
Concentration: 25, 50, 100, 200 µM
Incubation Time: 12h, 24 h
Result: Inhibited the migration of SMMC-7721 and Huh-7 cells in a dose-dependent manner, but had no effect on HL-7702 cells.

Apoptosis Analysis[2]

Cell Line: SMMC-7721, Huh-7
Concentration: 200 μM
Incubation Time: 24 h
Result: Remarkably increased the apoptotic index, protein expressions of cleaved caspase-3, 8, 9, cleaved PARP, as well as Bax/Bcl-2 and Bad/Bcl-xl ratios.
In Vivo

ATWLPPRAANLLMAAS (160-480 μg/kg; s.c.; once daily for 7 days) can significantly inhibit the growth of mouse xenograft sarcoma S180 and H22 liver cancer xenografts in a dose-dependent manner[1].
ATWLPPRAANLLMAAS (200 μg/kg; s.c.; once daily for 4 weeks) inhibits the growth of human HCC xenografts by downregulating angiogenesis and upregulating apoptosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1682.98

Formula

C76H123N21O20S
CAS No.
Sequence

Ala-Thr-Trp-Leu-Pro-Pro-Arg-Ala-Ala-Asn-Leu-Leu-Met-Ala-Ala-Ser
Sequence Shortening

ATWLPPRAANLLMAAS
SMILES

O=C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](N)C)=O)=O)CC3=CNC4=CC=CC=C34)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATWLPPRAANLLMAAS Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATWLPPRAANLLMAAS1228447-26-4ApoptosisRasRafMEKERKCaspasePARPBcl-2 FamilyRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasespoly ADP ribose polymerasesarcoma S180hepatoma H22BALB/c nude miceHepatocellular carcinoma (HCC)peptide V3apoptosisangiogenesissignaling pathwayHL-7702SMMC-7721Huh-7Inhibitorinhibitorinhibit

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