2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. AVE1231

AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation.

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AVE1231 Chemical Structure

AVE1231 Chemical Structure

CAS No. : 767334-89-4

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5 mg USD 790 In-stock
10 mg USD 1100 In-stock
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Description

AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation[1][2].

Molecular Weight

405.51

Formula

C20H27N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](C1=CC=C(OC)N=C1)CC)C2=CC=CC=C2NS(=O)(CCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (308.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4660 mL 12.3302 mL 24.6603 mL
5 mM 0.4932 mL 2.4660 mL 4.9321 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4660 mL 12.3302 mL 24.6603 mL 61.6508 mL
5 mM 0.4932 mL 2.4660 mL 4.9321 mL 12.3302 mL
10 mM 0.2466 mL 1.2330 mL 2.4660 mL 6.1651 mL
15 mM 0.1644 mL 0.8220 mL 1.6440 mL 4.1101 mL
20 mM 0.1233 mL 0.6165 mL 1.2330 mL 3.0825 mL
25 mM 0.0986 mL 0.4932 mL 0.9864 mL 2.4660 mL
30 mM 0.0822 mL 0.4110 mL 0.8220 mL 2.0550 mL
40 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.5413 mL
50 mM 0.0493 mL 0.2466 mL 0.4932 mL 1.2330 mL
60 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0275 mL
80 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7706 mL
100 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6165 mL
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AVE1231 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AVE1231767334-89-4A293AVE 1231AVE-1231A 293A-293Potassium ChannelKcsAPotassium channelsinhibitorsarrhythmiasInhibitorinhibitorinhibit

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