2. MAPK/ERK Pathway
  3. Raf MEK
  4. Avutometinib potassium

Avutometinib potassium  (Synonyms: Ro 5126766 potassium; CH5126766 potassium)

Cat. No.: HY-18652A
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Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that potently inhibits RAF/MEK kinase activity and induces dominant negative RAF-MEK complexes preventing phosphorylation of MEK by ARAF, BRAF and CRAF. Avutometinib (potassium) shows anti-proliferative potency across tumor cell lines carrying KRAS mutations including PDAC cell lines. Avutometinib (potassium) induces tumor inhibition and increases survival in a KRAS/p53 pancreatic cancer mouse model. Avutometinib (potassium) is promising for research of low-grade-serous-ovarian-carcinoma (LGSOC), ovarian cancer and pancreatic ductal adenocarcinoma (PDAC).

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Avutometinib potassium Chemical Structure

Avutometinib potassium Chemical Structure

CAS No. : 946128-90-1

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Avutometinib potassium Related Antibodies

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Description

Avutometinib (CH5126766) (potassium) is a RAF/MEK clamp that potently inhibits RAF/MEK kinase activity and induces dominant negative RAF-MEK complexes preventing phosphorylation of MEK by ARAF, BRAF and CRAF. Avutometinib (potassium) shows anti-proliferative potency across tumor cell lines carrying KRAS mutations including PDAC cell lines. Avutometinib (potassium) induces tumor inhibition and increases survival in a KRAS/p53 pancreatic cancer mouse model. Avutometinib (potassium) is promising for research of low-grade-serous-ovarian-carcinoma (LGSOC), ovarian cancer and pancreatic ductal adenocarcinoma (PDAC)[1][2].

Molecular Weight

510.56

Formula

C21H18FKN5O5S
CAS No.
SMILES

O=S(NC)(NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F)=O.[K]
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Room temperature in continental US; may vary elsewhere.
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Avutometinib potassium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avutometinib946128-90-1Ro 5126766CH5126766Ro5126766Ro-5126766CH 5126766CH-5126766RafMEKRaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KRAF/MEKARAFBRAFCRAFanti-proliferativetumor inhibitionmouseLGSOCovarian cancerPDACInhibitorinhibitorinhibit

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