2. Neuronal Signaling
  3. Beta-secretase
  4. AZ-4217

AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research.

For research use only. We do not sell to patients.

AZ-4217 Chemical Structure

AZ-4217 Chemical Structure

CAS No. : 1383846-83-0

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AZ-4217 Related Antibodies

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Description

AZ-4217 is an inhibitor for β-site amyloid precursor protein cleavage enzyme 1 (BACE1), with IC50 of 160 pM in human SH-SY5Y cells. AZ-4217 reduces amyloid deposition in Tg2576 mouse models, and is used for Alzheimer’s Disease research[1].

Molecular Weight

476.54

Formula

C30H25FN4O
CAS No.
SMILES

O=C(C(C)=C1)N(CC)C=C1[C@@]2(C3=CC(C4=CN=CC(C#CC)=C4)=CC=C3)C5=CC=CC(F)=C5C(N)=N2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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AZ-4217 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ-42171383846-83-0AZ4217AZ 4217Beta-secretaseBACEβ-SecretaseADAlzheimer’s DiseaseSH-SY5YC57BL/6 mouseTg2576Inhibitorinhibitorinhibit

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