AZ-TAK1

Cat. No.: HY-153320: FAQs
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AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines.

For research use only. We do not sell to patients.

AZ-TAK1 Chemical Structure

CAS No. : 1413440-36-4

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Purity & Documentation
References
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Description

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
LoVo	IC₅₀	75 nM Compound: 2	Growth inhibition of human LoVo cells after 96 hrs by SRB assay Growth inhibition of human LoVo cells after 96 hrs by SRB assay	[PMID: 30576901]
SK-CO-1	IC₅₀	61 nM Compound: 2	Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay	[PMID: 30576901]
SW-620	IC₅₀	38 nM Compound: 2	Growth inhibition of human SW620 cells after 96 hrs by SRB assay Growth inhibition of human SW620 cells after 96 hrs by SRB assay	[PMID: 30576901]

In Vitro

AZ-TAK1 (0.1μM) induces apoptosis in 28%, 24%, and 74% of Mino, SP53, and Jeko cells, respectively^[1].
AZ-TAK1 increases mitochondrial depolarization, indicated by a decrease in the red/green fluorescence intensity ratio^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

477.53

Formula

C₂₅H₂₈FN₇O₂

CAS No.

1413440-36-4

SMILES

FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Daniela Buglio, et al. Essential role of TAK1 in regulating mantle cell lymphoma survival. Blood. 2012 Jul 12;120(2):347-55. [Content Brief]

AZ-TAK1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ-TAK11413440-36-4MAP3KMAP kinase kinase kinase, MEKK, MAPKKKTHRβTAK1p38IκB-αmitochondrial depolarizationapoptosislymphomaInhibitorinhibitorinhibit

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